Selected Publications/Patents (Last 5 years):

• Singh M, Haque MA, Tikhomirov A, Shchekotikhin A, Das U, Kaur P (2022). Computational and biophysical characterization of heterocyclic derivatives of anthraquinone against Human Aurora Kinase A. ACS Omega (accepted).
• Sharma P, Kumar M, Tripathi MK, Gupta D, Vishwakarma P, Das U & Kaur P (2022). Genomic and structural mechanistic insight to reveal the differential infectivity of omicron and other variants of concern. Comput Biol Med 150, 106129.
• Sharma D, Singh M, Kaur P & Das U* (2022). Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity. Acta Crystallogr Sect D Struct Biol 78, 835–845.
• Gupta D, Kumar M, Singh M, Salman M, Das U & Kaur P (2022). Identification of polypharmacological anticancerous molecules against Aurora kinase family of proteins. J Cell Biochem 123, 719–735.
• Singh M, Malhotra L, Haque MA, Kumar M, Tikhomirov A, Litvinova V, Korolev AM, Ethayathulla AS, Das U, Shchekotikhin AE & Kaur P (2021). Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B. Biochimie 182, 152–165.
• Sabharwal N, Varshney K, Rath PP, Gourinath S & Das U* (2020). Biochemical and biophysical characterization of nucleotide binding domain of Trehalose transporter from Mycobacterium tuberculosis. Int J Biol Macromol 152, 109–116.
• Das U*, Singh E, Dharavath S, Tiruttani Subhramanyam UK, Pal RK, Vijayan R, Menon S, Kumar S, Gourinath S & Srinivasan A (2019). Structural insights into the substrate binding mechanism of novel ArgA from Mycobacterium tuberculosis. Int J Biol Macromol 125, 970–978.
• Gupta AK, Pokhriyal R, Das U, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachandran R, Goyal V, Tripathi M & Hariprasad G (2019). Evaluation of α-synuclein and apolipoprotein e as potential biomarkers in cerebrospinal fluid to monitor pharmacotherapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatr Dis Treat 15, 2073–2085.
• Das U, Pogenberg V, Subhramanyam UKT, Wilmanns M, Gourinath S & Srinivasan A (2014). Crystal structure of the VapBc-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent pin-domain ribonuclease and a variable mode of toxin-antitoxin assembly. J Struct Biol 188, 249–258.
• Das U, Kumar N, Gourinath S & Srinivasan A (2013). Preliminary crystallographic analysis of recombinant VapBC-15 toxin-antitoxin complex from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 69, 1242–1245.

Selected Publications/Patents (Last 5 years):

• Naz F, Kumar M, Koley T, Sharma P, Haque MA, Kapil A, Kumar M, Kaur P, Ethayathulla AS. Screening of plant-based natural compounds as an inhibitor of FtsZ from Salmonella Typhi using the computational, biochemical and in vitro cell-based studies. Int J Biol Macromol. 2022 Aug 3; 219: 428-437 doi: 10.1016/j.ijbiomac.2022.07.241
• Gupta V, Somarajan BI, Gupta S, Mahalingam K, Kumar M, Singh A. Association of EFEMP1 with juvenile-onset open angle glaucoma in a patient with concomitant COL11A1-related Stickler syndrome. Ophthalmic Genet. 2022 Aug 10:1-5. doi: 10.1080/13816810.2022.2109682.
• Koley T, Goswami A, Kumar M, Upadhyay N, Hariprasad G. Comparative Structural Analysis of Human ACE2 Receptor with Spike Protein of SARS-CoV-2 Variants: Implications to Understand Infectivity of the Virus. Adv Appl Bioinform Chem. 2022 Jun 16;15: 21-27. doi: 10.2147/AABC.S360787.
• Kulandaisamy R, Kushwaha T, Dalal A, Kumar V, Singh D, Baswal K, Sharma P, Praneeth K, Jorwal P, Kayampeta SR, Sharma T, Maddur S, Kumar M, Kumar S, Polamarasetty A, Singh A, Sehgal D, Gholap SL, Appaiahgari MB, Katika MR, Inampudi KK. Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and in vitro Studies. Front Microbiol. 2022 May 10; 13: 877813. doi: 10.3389/fmicb.2022.877813.
• Koley T, Chowdhury SR, Kushwaha T, Kumar M, Inampudi KK, Kaur P, Singh TP, Viadiu H, Ethayathulla AS. Deciphering the mechanism of p73 recognition of p53 response elements using the crystal structure of p73-DNA complexes and computational studies. Int J BiolMacromol. 2022 May 1; 206:40-50. doi: 10.1016/j.ijbiomac.2022.02.108.
• Anand V, Aggarwa B, Jauhari P, Kumar M, Gupta N, Kumar A, Gulati S, Kabra M. STAMBP gene mutation causing microcephaly-capillary malformation syndrome: a recognizable developmental and epileptic encephalopathy. Epileptic Disord. 2022 Jun 1;24(3):602-605. English. doi: 10.1684/epd.2021.1411.
• Koley T, Kumar M, Goswami A, Ethayathulla AS, Hariprasad G. Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virus. Biochem Biophys Res Commun. 2022 Feb 12; 592: 51-53. doi: 10.1016/j.bbrc.2021.12.082.
• Kumar A, Sharma R, Faruq M, Kumar M, Sharma S, Werner R, Hiort O, Vandana J. Clinical, Biochemical, and Molecular Characterization of Indian Children with Clinically Suspected Androgen Insensitivity Syndrome. Sex Dev. 2021 Oct 22:1-12. doi: 10.1159/000519047.
• Mishra P, Tandon G, Kumar M, Paital B, Swain SS, Kumar S, Samanta L. Promoter sequence interaction and structure based multi-targeted (redox regulatory genes) molecular docking analysis of vitamin E and curcumin in T4 induced oxidative stress model using H9C2 cardiac cell line. J BiomolStructDyn. 2021 Aug 31:1-20. doi: 10.1080/07391102.2021.1970624.
• Sharma S, Kumar R, Jain A, Kumar M, Gauttam R, Banerjee R, Mukhopadhyay J, Tyagi JS. Functional insights into Mycobacterium tuberculosis DevR-dependent transcriptional machinery utilizing Escherichia coli. Biochem J. 2021 Aug 27;478(16):3079-3098. doi: 10.1042/BCJ20210268.
• Garg S, Khan SI, Malhotra RK, Sharma MK, Kumar M, Kaur P, Nag TC, Ray R, Bhatia J, Arya DS. Cardioprotective effects of azilsartan compared with that of telmisartan on an in vivo model of myocardial ischemia-reperfusion injury. J BiochemMolToxicol. 2021 Jul;35(7):e22785. doi: 10.1002/jbt.22785.
• Koley T, Madaan S, Chowdhury SR, Kumar M, Kaur P, Singh TP, Ethayathulla AS. Structural analysis of COVID-19 spike protein in recognizing the ACE2 receptor of different mammalian species and its susceptibility to viral infection. 3Biotech. 2021 Feb;11(2):109. doi: 10.1007/s13205-020-02599-2.
• Malhotra L, Goyal HKV, Jhuria S, Dev K, Kumar S, Kumar M, Kaur P, Ethayathulla AS. Curcumin rescue p53Y220C in BxPC-3 pancreatic adenocarcinomas cell line: Evidence-based on computational, biophysical, and in vivo studies. BiochimBiophysActa Gen Subj. 2021 Feb;1865(2):129807. doi: 10.1016/j.bbagen.2020.129807.
• Kumar S, Tyagi YK, Kumar M, Kumar S. Synthesis of novel 4-methylthiocoumarin and comparison with conventional coumarin derivative as a multi-target-directed ligand in Alzheimer's disease. 3 Biotech. 2020 Dec;10(12):509. doi: 10.1007/s13205-020-02481-1.
• Tripathi A, Kumar B, Kumar M, Kaur P, Sagi SSK. Quercetin Prophylaxis: A Novel Approach to Prevent Hypoxia-Mediated Increase in Oxidative Stress, Pde-5 Activity and Transvascular Leakage in the Lungs of Rats. HSOA J Pulmo Med Respir Res. 2020 6: 041 doi:10.24966/PMRR-0177/100041
• Garg S, Khan SI, Malhotra RK, Sharma MK, Kumar M, Kaur P, Nag TC, RumaRay, Bhatia J, Arya DS. The molecular mechanism involved in cardioprotection by the dietary flavonoid fisetin as an agonist of PPAR-γ in a murine model of myocardial infarction. Arch BiochemBiophys. 2020 Nov 15; 694:108572. doi: 10.1016/j.abb.2020.108572.
• Sharma P, Kumar M, Dahiya S, Sood S, Das BK, Kaur P, Kapil A. Structure based drug discovery and in vitro activity testing for DNA gyrase inhibitors of Salmonella entericaserovarTyphi. Bioorg Chem. 2020 Nov;104: 104244. doi: 10.1016/j.bioorg.2020.104244.
• Kumar S, Kumar M, Tyagi YK, Kumar S. Inhibition of Amyloid Fibrillation of HEWL by 4-Methylcoumarin and 4-Methylthiocoumarin Derivatives. Curr Pharm Biotechnol. 2021;22 (2):232-244. doi: 10.2174/1389201021666200915112849.
• Kumar A, Sharma R, Faruq M, Suroliya V, Kumar M, Sharma S, Werner R, Hiort O, Jain V. Spectrum of Pathogenic Variants in SRD5A2 in Indian Children with 46,XY Disorders of Sex Development and Clinically Suspected Steroid 5α-Reductase 2 Deficiency. Sex Dev. 2019;13 (5-6):228-239. doi: 10.1159/000509812.
• Naz F, Mashkoor M, Sharma P, Haque MA, Kapil A, Kumar M, Kaur P, Abdul Samath E. Drug repurposing approach to target FtsZ cell division protein from Salmonella Typhi. Int J BiolMacromol. 2020 Sep 15; 159:1073-1083. doi: 10.1016/j.ijbiomac.2020.05.063.
• Kulandaisamy R, Kushwaha T, Kumar V, De S, Kumar S, Upadhyay SK, Kumar M, Inampudi KK. Characterization of active/binding site residues of peptidyl-tRNA hydrolase using biophysical and computational studies. Int J BiolMacromol. 2020 Sep 15;159: 877-885. doi: 10.1016/j.ijbiomac.2020.05.133.
• Perveen S, Gupta N, Kumar M, Kaur P, Chowdhury MR, Kabra M. Spectrum of amyloglucosidase mutations in Asian Indian patients with Glycogen storage disease type III. Am J Med Genet A. 2020 May;182(5):1190-1200. doi: 10.1002/ajmg.a.61547.
• Tripathi A, Kumar M, Kaur P, Kumar B, Sagi SSK. Efficacy of Quercetin as a potent sensitizer of β2-AR in combating the impairment of fluid clearance in lungs of rats under hypoxia. RespirPhysiolNeurobiol. 2020 Feb;273: 103334. doi: 10.1016/j.resp.2019.103334.
• Pandey G, Bakhshi S, Kumar M, Thakur B, Jain P, Kaur P, Chauhan SS. Prognostic and therapeutic relevance of cathepsin B in pediatric acute myeloid leukemia. Am J Cancer Res. 2019 Dec 1; 9 (12): 2634-2649.
• Kumar A, Jain V, Chowdhury MR, Kumar M, Kaur P, Kabra M. Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature. J PediatrEndocrinolMetab. 2020 Jan 28;33(1):79-88. doi: 10.1515/jpem-2019-0234.
• Sudarshan S, Kumar M, Kaur P, Kumar A, G S, Sapra S, Gulati S, Gupta N, Kabra M, Roy Chowdhury M. Decoding of novel missense TSC2 gene variants using in-silico methods. BMC Med Genet. 2019 Oct 26;20(1):164. doi: 10.1186/s12881-019-0891-y.
• Yadav P, Kumar M, Bansal R, Kaur P, Ethayathulla AS. Structure model of ferrochelatase from Salmonella Typhi elucidating metalation mechanism. Int J BiolMacromol. 2019 Apr 15;127: 585-593. doi: 10.1016/j.ijbiomac.2019.01.066.
• Gupta N, Tewari VV, Kumar M, Langeh N, Gupta A, Mishra P, Kaur P, Ramprasad V, Murugan S, Kumar R, Jana M, Kabra M. Asparagine Synthetase deficiency-report of a novel mutation and review of literature. Metab Brain Dis. 2017 Dec;3 2(6):1889-1900. doi: 10.1007/s11011-017-0073-6.
• Yenamandra VK, Vellarikkal SK, Kumar M, Chowdhury MR, Jayarajan R, Verma A, Scaria V, Sivasubbu S, Ray SB, Dinda AK, Kabra M, Kaur P, Sharma VK, Sethuraman G. Application of whole exome sequencing in elucidating the phenotype and genotype spectrum of junctional epidermolysis bullosa: A preliminary experience of a tertiary care centre in India. J Dermatol Sci. 2017 Apr; 86(1):30-36. doi: 10.1016/j.jdermsci.2016.12.020.

Selected Publications/Patents (Last 5 years):

• Kotnala A, Senthilkumari S, Gong Wu, Stewart TG, Curcio CA, Halder N. Singh SB, Kumar A, Velpandian T. (2022): Retinal Pigment Epithelium in Human Donor Eyes Contains Higher Levels of Bisretinoids Including A2E in Periphery than Macula. Invest Ophthalmol Vis Sci. Jun 1; 63(6):6.
• Sharma HP, Halder N, Singh SB, Velpandian T. (2021): Evaluation of the Presence and Functional Importance of Nucleoside Transporters in Lacrimal Gland for Tear Disposition of Intravenously Injected Substrate in Rabbits. T.Curr Eye Res. 2021 Nov; 46(11):1659-1665. doi: 10.1080/02713683.2021.1925698. Epub 2021 May 30. PMID: 33941003.
• Moksha L, Halder N, Singh SB, Chawla R, Kumar A, Velpandian T. (2021): Pharmacoproteomic analysis of topical dapsone and prednisolone interventions in the aqueous humor of anterior uveitis. Exp Eye Res. 2021 May; 206:108534. doi: 10.1016/j.exer.2021.108534. Epub 2021 Mar 17. PMID: 33722510.
• Gowtham L, Halder N, Angmo D, Singh SB, Jayasundar R, Dada T, Velpandian T. (2021): Elevated histamine levels in aqueous humor of patients with glaucoma. Mol Vis. Sep 3; 27:564-573. eCollection 2021. PMID: 34531647.
• Nath M, Halder N, Chandra P, Singh SB, Deorari AK, Kumar A, Velpandian T. (2018): Ocular kinetics and safety of intravitreally injected angiotensin converting enzyme inhibitor lisinopril. Int J Retina Vitreous. Nov 14; 4:42. doi: 10.1186/s40942-018-0146-7. eCollection 2018. PMID: 30460043.
• Singh AP, Bajaj T, Gupta D, Singh SB, Chakrawarty A, Goyal V, Dey AB. (2018): Serum Mortalin Correlated with α-Synuclein as Serum Markers in Parkinson's Disease: A Pilot Study. S.Neuromolecular Med. Mar; 20(1):83-89. doi: 10.1007/s12017-017-8475-5. Epub 2018 Jan 6. PMID: 29307058.
• Sharma HP, Halder N, Singh SB, Velpandian T. (2018): Involvement of nucleoside transporters in the transcorneal permeation of topically instilled substrates in rabbits in-vivo. Eur J Pharm Sci. Mar 1; 114:364-371. doi: 10.1016/j.ejps.2017.12.027. Epub 2017 Dec 30. PMID: 29292018.
• Venkatesh P, Selvan H, Singh SB, Gupta D, Kashyap S, Temkar S, Gogia V, Tripathy K, Chawla R, Vohra R. (2017): Vitreous Amyloidosis: Ocular, Systemic, and Genetic Insights. Ophthalmology. Jul; 124(7):1014-1022. doi: 10.1016/j.ophtha.2017.03.011. Epub 2017 Apr 12. PMID: 28412068.

• Rastogi N, Singh A, Pandey SN, Sinha M, Bhushan A, Kaur P, Sharma S, Singh TP. (2014) Structure of the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut. FEBS J. 281:2871-82.
• Kumar S, Singh N, Sinha M, Dube D, Singh SB, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP. (2010): Crystal structure determination and inhibition studies of a novel xylanase and alpha-amylase inhibitor protein (XAIP) from Scadoxus multiflorus. FEBS J.: 277(13):2868-82.
• Mir, R., Singh, N., Vikram, G., Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2010). Structural and binding studies of C-terminal half (C-lobe) of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory Drugs (NSAIDs). Arch. Biochem. Biophy. 500, 196 - 202.
• Mir R, Kumar RP, Singh N, Vikram GP, Sinha M, Bhushan A, Kaur P, Srinivasan A, Sharma S, Singh TP. (2010). Specific interactions of C-terminal half (C-lobe) of lactoferrin protein with edible sugars: binding and structural studies with implications on diabetes. Int J Biol Macromol.47, 50-9.
• Sheikh, I.A., Singh, A.K., Singh, N., Sinha, M., Singh, S.B., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Structural evidence of substrate specificity in mammalian peroxidases: Structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4A resolution. J. Biol. Chem. 284, 14849 - 14856.
• Singh, A.K., Kumar, R.P., Pandey, N., Singh, N., Sinha, M., Bhushan, A., Kaur, P., Sharma, S. & Singh, T.P. (2009). Mode of binding of the tuberculosis prodrug isoniazid to peroxidases: Crystal structure of bovine lactoperoxidase with isoniazid at 2.7A resolution. J. Biol. Chem. 285, 1569 - 1576.
• Mir, R., Singh, N., Vikram, G., Kumar, R.P., Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009)). Structural basis of the prevention NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe) of bovine colostrums protein lactoferrin: Binding and structural studies of the C-lobe complexes with indomethacin, diclofenac, aspirin and ibuprofen. Biophys. J. 97, 3178 – 3186.
• Singh, R.K., Ethayathulla, A.S., Jabeen, T., Sharma, S., Kaur, P. & Singh, T.P. (2005). Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A2: Crystal structure of the complex formed between phospholipase A2 and aspirin at 1.9 Å resolution. J. Drug Target. 13, 113 – 119.

Selected Publications/Patents (Last 5 years):

• Ahmad N, Singh A, Gupta A, Pant P, Singh TP, Sharma S, Sharma P. Discovery of the Lead Molecules Targeting the First Step of the Histidine Biosynthesis Pathway of Acinetobacter baumannii. J Chem Inf Model. (2022) 62 :1744-1759.
• Sikarwar J, Singh J, Singh TP, Sharma P, Sharma S. The mechanism of action of Lactoferrin - Nucleoside Diphosphate Kinase complex in combating biofilm formation. Protein Pept Lett. (2022) Aug 16. doi: 10.2174/0929866529666220816160517.
• Singh PK, Ahmad N, Yamini S, Singh RP, Singh AK, Sharma P, Smith ML, Sharma S, Singh TP. Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase. Protein Sci. (2022) 31:384-395.
• Singh J, Maurya A, Singh PK, Viswanathan V, Ahmad MI, Sharma P, Sharma S, Singh TP. A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 Å Resolution. Protein J. (2021) 40 :857-866.
• Gupta A, Vijayan V, Pant P, Kaur P, Singh TP, Sharma P, Sharma S. Structure prediction and discovery of inhibitors against phosphopantothenoyl cysteine synthetase of Acinetobacter baumannii. J Biomol Struct Dyn. (2021) Aug 4:1-13
• Singh A, Ahmad N, Varadarajan A, Vikram N, Singh TP, Sharma S, Sharma P. Lactoferrin, a potential iron-chelator as an adjunct treatment for mucormycosis - A comprehensive review. Int J Biol Macromol. (2021) Sep 30;187:988-998.
• Singh J, Vijayan V, Ahmedi S, Pant P, Manzoor N, Singh TP, Sharma P, Sharma S. Lactosmart: A Novel Therapeutic Molecule for Antimicrobial Defense. Front Microbiol. (2021) 12:672589.
• Gupta A, Sharma P, Singh TP & Sharma S. Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochim Biophys Acta Proteins Proteom (2021) 1869:140566.
• Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S & Singh TP Structure of Yak Lactoperoxidase at 1.55 Å Resolution. Protein J. (2021) 40:8-18.
• Singh PK, Pandey S, Rani C, Ahmad N, Viswanathan V, Sharma P, Kaur P, Sharma S & Singh TP. Potassium-induced partial inhibition of lactoperoxidase: structure of the complex of lactoperoxidase with potassium ion at 2.20 Å resolution. J Biol Inorg Chem (2021) 26: 149-159.
• Sharma P, Singla A, Gupta A, Khan NI, Rani C, Singh TP & Sharma S. Biophysical characterization of Type III Pantothenate kinase (PanK) from Acinetobacter baumannii. Protein Pept Lett (2021) 28(4), 450-458.
• Sharma P, Vijayan V, Pant P, Sharma M, Vikram N, Kaur P, Singh TP, Sharma S. Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2. J Biomol Struct Dyn. 2020; 3:1-11.
• Gupta A, Singh PK, Iqbal N, Sharma P, Baraigya HR, Kaur P, Umar MS, Ahmad F, Sharma A, Owais M, Sharma S, Singh TP. Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Biochim Biophys Acta Proteins Proteom. (2019) 1867:537-547.
• Pandey SN, Iqbal N, Singh PK, Rastogi N, Kaur P, Sharma S & Singh TP. Binding and structural studies of the complexes of type 1 ribosome inactivating protein from Momordica balsamina with uracil and uridine. Proteins. (2019) 87:99-109.
• Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S & Singh TP. A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. (2018) 644:72-80.
• Kaushik S, Iqbal N, Singh N, Sikarwar JS, Singh PK, Kaur P, Sharma S & Singh TP. Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies. Biochem J. (2018) 475:547-560.
• Singh PK, Iqbal N, Sirohi HV, Bairagya HR, Kaur P, Sharma S & Singh TP. Structural basis of activation of mammalian heme peroxidases. Prog Biophys Mol Biol. (2018)133:49-55.
• Singh PK, Sirohi HV, Iqbal N, Tiwari P, Kaur P, Sharma S, Singh TP. Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98Å resolution. Biochim Biophys Acta. (2017) 1865:329-335.
• Iqbal N, Kumar M, Sharma P, Yadav SP, Kaur P, Sharma S, Singh TP. Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii. Int J Biol Macromol. (2017) 94:459-465.
• Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP. Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. (2017) 85:1882-1890.
• Singh RP, Singh A, Sirohi HV, Singh AK, Kaur P, Sharma S, Singh TP. Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases - structural determination of the lactoperoxidase-methimazole complex at 1.97 Å resolution. FEBS Open Bio. (2016) 6:640-50.
• Rastogi N, Singh A, Singh PK, Tyagi TK, Pandey S, Shin K, Kaur P, Sharma S, Singh TP. Structure of iron saturated C-lobe of bovine lactoferrin at pH 6.8 indicates a weakening of iron coordination. Proteins. (2016) 84:591-9.

• Dubey V, Roy A, Dixit AB, Tripathi M, Pandey S, Jian S, Chandra PS, Banerjee J*. Dendritic reorganization in the hippocampus, anterior temporal lobe, and frontal neocortex of lithium-pilocarpine induced Status Epilepticus (SE). 2023, Journal of Chemical Neuroanatomy, 133: 102319. doi: 10.1016/j.jchemneu.2023.102329.
• Kumar K, Dubey V, Zaidi SS, Tripathi M, Siraj F, Sharma MC, Chandra PS, Doddamani R, Dixit AB, Banerjee J*. RNA Sequencing of Intraoperative Peritumoral Tissues Reveals Potential Pathways Involved in Glioma-Related Seizures. 2023, Journal of Molecular Neuroscience, 73:437-447. doi: 10.1007/s12031-023-02125-y.
• Dubey V, Dixit AB, Banerjee J*. Tempol Suppresses Generalized seizures in animal model of epilepsy. 2023, Neurology India, 71:412-413. doi: 10.4103/0028-3886.375411.
• Sharma D, Tripathi M, Doddamani R, Sharma MC, Lalwani S, Chandra PS, Dixit AB, Banerjee J*. Correlation of Age at Seizure Onset with GABAA receptor subunit and Chloride Co-transporter configuration in Focal Cortical Dysplasia (FCD). 2023, Neuroscience Letters, 796: 137065. doi: 10.1016/j.neulet.2023.137065. (IF-3.1).
• Chakraborty A, Dey S, Kumar K, Dixit AB, Tripathi M, Sharma MC, Chandra PS, Banerjee J*. Novel variants in GABAA receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy. 2023, Epilepsy Research, 189:107056. doi: 10.1016/j.eplepsyres.2022.107056.
• Kumar K, Banerjee Dixit A, Tripathi M, Dubey V, Siraj F, Sharma MC, Lalwani S, Chandra PS, Banerjee J*. Transcriptomic profiling of nonneoplastic cortical tissues reveals epileptogenic mechanisms in dysembryoplastic neuroepithelial tumors. 2022, Functional & Integrative Genomics; 22:905-917. doi: 10.1007/s10142-022-00869-1.
• Bera A, Srivastava A, Dubey V, Dixit AB, Tripathi M, Sharma MC, Lalwani S, Chandra PS, Banerjee J*. Altered hippocampal expression and function of cytosolic phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE). 2022, Neurological Research; 44: 748-753.doi: 10.1080/01616412.2022.2051131.
• Dubey V, Dey S, Dixit AB, Tripathi M, Chandra PS, Banerjee J*. Differential glutamate receptor expression and function in the hippocampus, anterior temporal lobe and neocortex in a pilocarpine model of temporal lobe epilepsy. 2022, Experimental Neurology;347:113916. doi: 10.1016/j.expneurol.2021.113916.
• Dey S, Banerjee Dixit A, Tripathi M, Doddamani RS, Sharma MC, Lalwani S, Chandra PS, Banerjee J*. Altered hippocampal kynurenine pathway metabolism contribute to hyperexcitability in human mesial temporal lobe epilepsy-hippocampal sclerosis. 2021, British Journal of Pharmacology; 178:3959-3976.doi: 10.1111/bph.15534.
• Kumar S, Shanker OR, Kumari N, Tripathi M, Chandra PS, Dixit AB, Banerjee J*. Neuromodulatory effects of SARS-CoV2 infection: Possible therapeutic targets. 2021, Expert Opinion on Therapeutic Targets; 25:509-519.doi: 10.1080/14728222.2021.1953475.
• Banerjee J, Srivastava A, Sharma D, Dey S, Tripathi M, Sharma MC, et al. Differential regulation of glutamatergic activity in the hippocampus and anterior temporal lobe by cyclin dependent kinase 5 (Cdk5) in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 2021, Neuroscience Letters; 761: 136096. doi: 10.1016/j.neulet.2021.136096.
• Dey S, Doddamani R, Dixit AB, Tripathi M, Sharma MC, Chandra PS, Banerjee J*. Altered spontaneous glutamatergic and GABAergic activity in the peritumoral cortex of low-grade gliomas presenting with history of seizures. 2021, Frontiers in Neuroscience; 15:689769. doi:10.3389/fnins.2021.689769
• Sharma D, Dixit AB, Dey S, Tripathi M, Doddamani R, Sharma MC, Lalwani S, Gurjar HK, Chandra PS, Banerjee J*. Increased levels of α4-containing GABAA receptors in focal cortical dysplasia: A possible cause of benzodiazepine resistance. 2021, Neurochemistry International; 148:105084.doi: 10.1016/j.neuint.2021.105084
• Banerjee J*, Dey S, Dixit AB, Doddamani R, Sharma MC, Garg A, et al. GABAA Receptor-Mediated Epileptogenicity in Focal Cortical Dysplasia (FCD) Depends on Age at Epilepsy Onset. 2020, Front Cell Neurosci; 14:562811.doi: 10.3389/fncel.2020.562811.
• Banerjee J*, Dey S, Dixit AB, Tripathi M, Doddamani R, Sharma MC, et al. α7 nicotinic receptors contributes to glutamatergic activity in the hippocampus of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). 2020, J Neural Transmission; 127:1441-1446.doi: 10.1007/s00702-020-02239-2.
• Banerjee J, Tripathi M, Chandra PS, Dixit AB. Do SARS-CoV2 viral proteins have neuromodulatory properties? 2020, Neurol India; 68:274-275.doi: 10.4103/0028-3886.283760.
• Srivastava A, Dixit AB, Paul D, Tripathi M, Sarkar C, Chandra PS, Banerjee J* (2017). Comparative analysis of cytokine/chemokine regulatory networks in patients with hippocampal sclerosis (HS) and focal cortical dysplasia (FCD). Scientific Reports, 7:15904.doi: 10.1038/s41598-017-16041-w.
• Banerjee J*, Dixit AB, Srivastava A, Ramanujam B, Kakkar A, Sarkar C, Tripathi M & Chandra PS (2017). Altered glutamatergic tone reveals two distinct resting state networks at the cellular level in hippocampal sclerosis. Scientific Reports, 7:319.doi: 10.1038/s41598-017-00358-7.

Selected Publications/Patents (Last 5 years)

PATENTS:

• Saroj Kumar, Simran Rastogi and Komal Rani. 2022. “A Composition for Isolating Exosomes and Method Thereof”. Patent Application Number: 202211022537.
• Gyan Prakash Modi, Himanshu Rai, Rishabh Singh, Saroj Kumar, Gauri Shankar, Brijesh Singh, Sarika Gupta, Saripella Srikrishna, Sairam Krishnamurthy. 2022. “An Imaging Probe for Detection of Key Biomarkers in Alzheimer Disease”. Reference/identification number of the patent: 6457IN034.
• Gyan Prakash Modi, Yash Pal Singh, C. Praveen Kumar, Meenu Yadav, Gauri Shankar, Gourav Singh, Saroj Kumar, S Srikrishna. 2021. “A multifunctional diarylurea-hydroxyamidine based compound for treatment of Alzheimer’s disease”. TEMP/E-1/1680/2021-DEL. Patent App. No: 202111001482; Ref. No. P.2116.IN. (Patent Filed Jan 2021).

PUBLICATIONS: (Last 5 years):

• Priya Kumari Gorai, Simran Rastogi, Prahalad Singh Bharti, S Shivani, Priyanka Soni, Harshit Jain, Seema Singh, Shipra Agarwal, Sujoy Pal, Tapas Chandra Nag, Renu Dhingra, Mehar Chand Sharma, Rakesh Kumar, Fredrik Nikolajeff, Saroj Kumar*, Neerja Rani*. 2023. “Plasma-derived extracellular vesicles reveal pancreatic neuroendocrine tumors.” Molecular Oncology. (Under Review, MOLONC-23-0074) (IF: 7.449)
• Abhay Mishra, Prahalad Singh Bharti, Fredrik Nikolajeff, Saroj Kumar*. 2023. “A Tale of Exosomes and their Implication in Cancer”. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. (Under Review, BBACAN-D-23-00038) (IF: 11.414)
• Simran Rastogi, Komal Rani, Vaibhav Sharma, Prahalad Singh Bharti, Krishna Deo, Veena Jain, Aditi Nanda, Saroj Kumar*, Dheeraj Kumar Koli*. 2023. “Osteogenic markers in perimplant crevicular fluid (PICF) in immediate and delayed loaded dental implants: A randomized controlled trial”. Clinical Implant Dentistry and Related Research. (Under Revision, CID-22-290.R2) (IF: 4.259)
• Simran Rastogi, Komal Rani, Sanskriti Rai, Rishabh Singh, Vaibhav Sharma, Prahalad Singh Bharti, Vrinda Kapoor, Poorvi Vishwakarma, Shivaji Gholap, Krishna Inampudi, Gyan Prakash Modi, Neerja Rani, Madhavi Tripathi, Achal Srivastava, Roopa Rajan, Fredrik Nikolajeff, Saroj Kumar*. 2023. “Fluorescence tagged salivary exosomes as a nano tool in early diagnosis of Parkinson’s disease”. Translational Neurodegeneration. (Under Revision, TNEU-D-22-00393R1) https://doi.org/10.21203/rs.3.rs-1621589/v1 (IF: 9.88)
• Vaibhav Sharma, Fredrik Nikolajeff, Saroj Kumar*. 2023. “Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases”. Translational Neurodegeneration (Accepted, TNEU-D-22-00341) (IF: 9.88)
• Sunil Kumar, Faheem Abbas, Iqra Ali, Manoj K Gupta, Saroj Kumar, Deepak Kumar. 2023. Integrated network pharmacology and in-silico approaches to decipher the pharmacological mechanism of Selaginella tamariscina in the treatment of non-small cell lung cancer. Phytomedicine Plus. (Accepted, PHYPLU_100419)
• Vaibhav Sharma, Saptamita Paul Choudhury, Saroj Kumar, Fredrik Nikolajeff. 2023. “Saliva based diagnostic methodologies for a fast-track detection of autism spectrum disorder: A mini-review”. Frontiers in Neuroscience. 2023;16. https://doi.org/10.3389/fnins.2022.893251 (IF: 5.152)
• Himanshu Rai, Sarika Gupta, Saroj Kumar, Jian Yang, Sushil K Singh, Chongzhao Ran, Gyan Modi. 2022. “Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid Beta and Tau Aggregates in Alzheimer’s Disease”. ACS Journal of Medicinal Chemistry (Accepted) https://doi.org/10.1021/acs.jmedchem.1c01619 (IF: 7.446)
• Vaibhav Sharma, Saptamita Choudhury, Srijon Sen, Sarika Bano, Kapil Suchal, Saroj Kumar, Fredrik Nikolajeff, and Sanjay Dey. 2022. “Altered Neural Cell Junctions and Ion-channels Leading to Disrupted Neuron Communication in Parkinson’s Disease”. NPJ Parkinson's Disease 8 (1): 66. https://doi.org/10.1038/s41531-022-00324-9 (IF: 9.304)
• Rajkumar Kulandaisamy, Tushar Kushwaha, Anu Dalal, Vikas Kumar, Deepa Singh, Kamal Baswal, Pratibha Sharma, Kokkula Praneeth, Pankaj Jorwal, Sarala R Kayampeta, Tamanna Sharma, Srinivas Maddur, Manoj Kumar, Saroj Kumar, Aparoy Polamarasetty, Aekagra Singh, Deepak Sehgal, Shivajirao L Gholap, Mohan B Appaiahgari, Madhumohan R Katika, Krishna K Inampudi. 2022. “Repurposing of FDA Approved Drugs Against SARS-CoV-2 Papain-Like Protease: Computational, Biochemical, and in Vitro Studies.” Frontiers in Microbiology 13: 877813. https://www.frontiersin.org/article/10.3389/fmicb.2022.877813 (IF: 5.640)
• Nithin KV, Veena Jain, Dheeraj Kumar Koli, Saroj Kumar, Aditi Nanda. 2022. “Comparative Evaluation of Osteocalcin in Peri-Implant Crevicular Fluid and Radiographic Bone Loss in Immediate Loading and Delayed Loading Protocols: A Preliminary Split-Mouth Randomized Controlled Trial”. International Journal of Prosthodontics 35 (2): 174–180. http://dx.doi.org/10.11607/ijp.7489 (IF: 1.785)
• Rastogi, Simran, Komal Rani, and Saroj Kumar*. 2021. “Progression of Cognitive Impairment to Alzheimer’s Disease: Through the Lens of Salivary Extracellular Vesicles.” Neuroscience Insights 16: 26331055211058690. https://doi.org/10.1177/26331055211058687 (IF: 2.640)
• Singh Y, Kumar N, Khushbu P, Chauhan BS, Shankar G, Kumar S, Singh G, Srikrishna S, Garg P, Singh G, Rai G, Modi GP*. 2021. Exploration of Neuroprotective Properties of Naturally Inspired Multifunctional Molecule (F24) Against Oxidative Stress and Amyloid β Induced Neurotoxicity in Alzheimer's Disease Models. ACS Chemical Neuroscience 13 (1): 27-42. https://doi.org/10.1021/acschemneuro.1c00443 (IF: 5.780)
• Yash Pal Singh, Himanshu Rai, Gourav Singh, Gireesh Kumar Singh, Sunil Mishra, Saroj Kumar, S. Srikrishna, and Gyan Modi. 2021. “A Review on Ferulic Acid and Analogs Based Scaffolds for the Management of Alzheimer’s Disease.” European Journal of Medicinal Chemistry 215: 113278. https://doi.org/10.1016/j.ejmech.2021.113278 (IF: 7.088)
• Simran Rastogi, Vaibhav Sharma, Prahalad Singh Bharti, Komal Rani, Gyan P. Modi, Fredrik Nikolajeff, and Saroj Kumar*. 2021. “The Evolving Landscape of Exosomes in Neurodegenerative Diseases: Exosomes Characteristics and a Promising Role in Early Diagnosis.” International Journal of Molecular Sciences 22 (1): 440. https://doi.org/10.3390/ijms22010440 (IF: 6.208)
• Komal Rani, Simran Rastogi, Poorvi Vishwakarma, Prahalad Singh Bharti, Vaibhav Sharma, Km Renu, Gyan P. Modi, Venugopalan Y. Vishnu, Prashun Chatterjee, Aparajit Ballav Dey, Fredrik Nikolajeff, and Saroj Kumar*. 2021. “A Novel Approach to Correlate the Salivary Exosomes and Their Protein Cargo in the Progression of Cognitive Impairment into Alzheimer’s Disease.” Journal of Neuroscience Methods 347: 108980. https://doi.org/10.1016/j.jneumeth.2020.108980 (IF: 2.987)
• Lakshay Malhotra, Harsh K. V. Goyal, Sunita Jhuria, Kapil Dev, Saroj Kumar, Manoj Kumar, Punit Kaur, and Abdul S. Ethayathulla*. 2021. “Curcumin Rescue P53Y220C in BxPC-3 Pancreatic Adenocarcinomas Cell Line: Evidence-Based on Computational, Biophysical, and in Vivo Studies.” Biochimica et Biophysica Acta (BBA) - General Subjects 1865 (2): 129807. https://doi.org/10.1016/j.bbagen.2020.129807 (IF: 4.117)
• Simran Rastogi, Komal Rani, Fredrik Nikolajeff, and Saroj Kumar*. 2020. “Finding a Novel Method to Understand the Role of Salivary Exosome in Progression of Cognitive Impairment to Alzheimer’s Disease.” Alzheimer’s & Dementia 16 (S4): e041920. https://doi.org/10.1002/alz.041920 (IF: 21.566)
• Vaibhav Sharma, Simran Rastogi, Kaushal Kumar Bhati, Alagiri Srinivasan, Ajoy Roychoudhury, Fredrik Nikolajeff, and Saroj Kumar*. 2020. “Mapping the Inorganic and Proteomic Differences among Different Types of Human Teeth: A Preliminary Compositional Insight.” Biomolecules 10 (11): 1540. https://doi.org/10.3390/biom10111540 (IF: 6.064)
• Rajkumar Kulandaisamy, Tushar Kushwaha, Vikas Kumar, Soumya De, Saroj Kumar, Santosh Kumar Upadhyay, Manoj Kumar, Krishna K. Inampudi*. 2020. "Characterization of active/binding site residues of peptidyl-tRNA hydrolase using biophysical and computational studies". International Journal of Biological Macromolecules 159: 877-885. https://doi.org/10.1016/j.ijbiomac.2020.05.133 (IF: 6.953)
• Vaibhav Sharma, Alagiri Srinivasan, Fredrik Nikolajeff, Saroj Kumar*. 2020. "Biomineralization Process in Hard Tissues: The Interaction Complexity within Protein and Inorganic Counterparts". Acta Biomaterialia 120: 20-37. https://doi.org/10.1016/j.actbio.2020.04.049 (IF: 10.633)
• Komal Rani, Mitali Tyagi, Mohit Majumdar, Akanksha Singh, Annaian Shanmugam, Krishna Dalal, Manoj Pillai, Gourinath Samudrala, Saroj Kumar, Alagiri Srinavasan*. 2020. “Accelerated identification of serine racemase inhibitor from Centella asiatica". Scientific Reports 10 (1): 4640. https://doi.org/10.1038/s41598-020-61494-1 (IF: 5.134)
• Javeed Ahmad, Mohd Khubaib, Javaid Ahmad Sheikh, Rita Pancsa, Saroj Kumar, A. Srinivasan, M. A. Al-Dosary. 2020. "Targeting the Hsp90 Inhibitors Against SARS-CoV-2 Protein: A Computational Study". Virus Research 290: 198173. https://doi.org/10.1016/j.virusres.2020.198173 (IF: 4.034)
• Rakesh Kumar, Maheswari S, Sneha R. Kumari, Sharanya S. S., and Saroj Kumar*. 2020. “Characterization of Exosomes from Saliva and Their Cargo in Human Papilloma Virus Infected Patients.” Journal of Clinical Medicine 9 (11): 3584. https://doi.org/10.3390/jcm9113584 (IF: 4.242)
• Yadav J.P., Kumar S. 2019. “Endoplasmic Reticulum Stress Response in the Pathophysiology of Neurodegenerative Diseases”. Reviews in the Neurosciences 30: 521-532. https://doi.org/10.1515/revneuro-2019-0030 (IF: 1.747)
• Sumesh S., Garg S., Kumar S., Pandey D., Yadav R., Sahai S., Shrivastava S., and Tiwari M. 2019. “Association between the function of mitochondrial dynamics and autophagy in neurodegenerative diseases”. Journal of Molecular Neuroscience 67: 322-332. https://doi.org/10.1007/s12031-019-01377-2 (IF: 3.141)
• Sunil K, Ashok Kumar, Ranjan Roy, Sumesh S, Deepak N. 2019. “Biochemical Alterations of the Plasma Membrane in Alzheimer's Disease”. Journal of Alzheimer's Disease 72(3): 877-883. https://doi.org/10.3233/JAD-190485 (IF: 5.982)
• Gaurav R. Kumar, Vishal Srivastava, Vaibhav S. Choudhury, Shankar G. Kumar, Saroj Kumar, Meenakshi. 2018. “Drug Repositioning: A Revolutionary Approach for the Treatment of Alzheimer’s Disease”. Future Medicinal Chemistry 10(8): 877-883. https://doi.org/10.1016/j.jom.2018.08.123 (IF: 6.510)
• Deepak S, Saroj K, Sachin S, Suneel R, Krishna G., Swati S, Renu D, Komal S. 2018. “Neurodegenerative Diseases and Potential Role of Exosomes in Their Diagnosis.” Cellular and Molecular Neurobiology 38(4): 597-608. https://doi.org/10.1007/s10571-017-0545-5 (IF: 5.378)

Selected Publications/Patents (Last 5 years):

• Rajkumar Kulandaisamy, Tushar Kushwaha, Anu Dalal, Vikas Kumar, Deepa Singh, Kamal Baswal, Pratibha Sharma, Kokkula Praneeth, Pankaj Jorwal, Srinivas Maddur, Tamanna Sharma, Manoj Kumar, Saroj Kumar, Aparoy Polamarasetty, Aekera Singh, Deepak Sehgal, Shivajirao L Gholap, Mohan B Appaiahgari, Madhumohan R Katika, Krishna K Inampudi. "Repurposing of FDA approved drugs against SARS-CoV-2 Papain-Like protease by using computational, biochemical and in vitro studies," 2022. Frontiers in Microbiology 13, 877813, 1-23. Corresponding author* (Impact factor: 6.06)
• Preeti Hooda, Mohd Ishtikhar, Shweta Saraswat, Pooja Bhatia, Deepali Mishra, Aditya Trivedi, Rajkumar Kulandaisamy, Soumya Aggarwal, Manoj Munde, Nemat Ali, Abdullah F. AlAsmari, Mohd A. Rauf, Krishna K. Inampudi, and Deepak Sehgal. "Biochemical and Biophysical Characterisation of the Hepatitis E Virus Guanine-7-Methyltransferase," 2022. Molecules, 27, 1505. * Corresponding author. (Impact factor: 4.92)
• Anu Dalal, Tushar Kushwaha, Gourav Choudhir, Krishna K Inampudi, Tarak Karmakar, P Hariprasad, Shivajirao L Gholap. "Computational investigations on the potential role of hygrophorones as quorum sensing inhibitors against LasR protein of Pseudomonas aeruginosa," 2022. J Biomol Struct Dyn 25;1-11. (Impact factor: 5.23)
• Ravi Bharadwaj, Tushar Kushwaha, Azhar Ahmad, Krishna K Inampudi, Tomoyoshi Nozaki and Somlata. "An atypical EhGEF regulates phagocytosis in Entamoeba histolytica through EhRho1," 2021. PLOS Pathogens 17: 1-36. (Impact factor: 7.46)
• Rajkumar K, Tushar K, Vikas Kumar, Soumya De, Manoj Kumar, Saroj Kumar, Santosh K Upadhyay, Krishna K Inampudi. "Characterization of Active/Binding Site Residues of peptidyl-tRNA Hydrolase Using Biophysical and Computational Studies," 2020. International Journal of Biological Macromolecules 159: 877-885. * Corresponding author. (Impact factor: 8.02)
• Sayantani Roy, Soumendu Boral, Snigdha Maiti, Tushar Kushwaha, Aditya J. Basak, Woonghee Lee, Amit Basak, Shivajirao L. Gholap, Krishna K. Inampudi and Soumya De. "Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition," 2021. The FEBS Journal 1-18. (Impact factor: 5.62)
• Sulaiman A, McGarry S, El-Sahli S, Li L, Chambers J, Phan A, Al-Kadi E, Krishna K Inampudi, Gadde S, Wang L. "Nanoparticles loaded with Wnt and YAP/mevalonate inhibitors in combination with paclitaxel stop the growth of TNBC patient-derived xenografts and diminish cancer stem cells and tumorigenesis," 2020. Advanced Therapeutics 3(11), 1-14.
• A. Carolin Seefeldt, Fabian Nguyen, Stéphanie Antunes, Natacha Pérébaskine, Michael Graf, Stefan Arenz, Krishna K Inampudi, Céline Douat, Gilles Guichard, Daniel N. Wilson & C. Axel Innis. "The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the post-initiation complex," 2015. Nature Structural & Molecular Biology 22: 470-475. (Impact factor: 18.36)
• Stanley Howell, Krishna K. Inampudi, Doyle P Bean and Corey J. Wilson. "Understanding thermal adaptation of enzymes through the multistate rational design and stability prediction of 100 adenylate kinases," 2014. Structure 22: 218-29. (Impact factor: 5.87) * equally contributed to this work.
• Paul A. Beales, Nienke Geerts, Krishna K. Inampudi, Corey J. Wilson and T. Kyle Vanderlick. "Reversible assembly of stacked membrane nano-platforms with reduced dimensionality and variable periodicity," 2013. Journal of American Chemical Society 135: 3335-8. (Impact factor: 16.38)
• Sarai Meyer, Roee Ramot, Krishna K. Inampudi, Beibei Luo, Chenyu Lin, Swathi Amere and Corey J. Wilson. "Engineering alternate cooperative-communications in the lactose repressor protein scaffold," 2013. Protein Engineering Design and Selection 6: 433-443. * equally contributed to this work. (Impact factor: 1.95)
• Roee Ramot, Krishna K. Inampudi and Corey J. Wilson. "The Lactose Repressor Experimental Folding Landscape: Fundamental Functional Unit and Tetramer Folding Mechanisms," 2012. Biochemistry 51: 7569–79. (Impact factor: 3.16)
• Kayode K. Ojo, Eric T. Larson, Katelyn R. Keyloun, Lisa J. Castaneda, Amy E. DeRocher, Krishna K. Inampudi, Jessica E. Kim, Tracy L. Arakaki, Ryan Murphy, Li Zhang, Alberto J. Napuli, Dustin J. Maly, Christophe L. M. J. Verlinde, Frederick S. Buckner, Marilyn Parsons, Wim G. J. Hol, Ethan A. Merritt and Wesley C. VanVoorhis. "A Unique Variation of the ATP binding site makes Toxoplasma gondii Calcium-Dependent Protein Kinase 1 a drug target for selective kinase inhibitors," 2010. Nature Structural & Molecular Biology 17: 602-07. (Impact factor: 18.36)

Recent Publications:

• Yadav P, Kumar M, Bansal R, Kaur P, Ethayathulla AS. Structure model of ferrochelatase from Salmonella Typhi elucidating metalation mechanism. Int J Biol Macromol. 2019 Apr 15;127:585-593.
• Bansal R, Haque MA, Yadav P, Gupta D, Ethayathulla AS, Hassan MI, Kaur P. Estimation of structure and stability of MurE ligase from Salmonella enterica serovar Typhi. Int J Biol Macromol. 2018 Apr 1;109:375-382.
• Gupta D, Sachdeva E, Haque MA, Rahman S, Bansal R, Ethayathulla AS, Hassan MI, Kaur P. Effect of chemical denaturants on the conformational stability of GyrB subunit of DNA gyrase from Salmonella enterica serovar Typhi. Int J Biol Macromol. 2017 May 9;103:165-174.
• Khan MI, Gupta AK, Kumar DR, Kumar M, Ethayathulla AS, Hariprasad G. Molecular modeling of Gly80 and Ser80 variants of human group IID phospholipase A2 and their receptor complexes: potential basis for weight loss in chronic obstructive pulmonary disease. J Mol Model. 2016 Sep;22(9):232.
• Ramos A, Tse PW, Wang J, Ethayathulla AS, Viadiu H. Sequence Variation in the Response Element Determines Binding by the Transcription Factor p73. Biochemistry. 2015 Dec 1;54(47):6961-72.
• Tikhonova EB, Ethayathulla AS, Su Y, Hariharan P, Xie S, Guan L. A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen. Sci Rep. 2015 Jan 28;5:8070.
• Amin A, Ethayathulla AS, Guan L. Suppression of conformation-compromised mutants of Salmonella enterica serovar Typhimurium MelB. J Bacteriol. 2014;196(17):3134-9.
• Ethayathulla AS, Yousef MS, Amin A, Leblanc G, Kaback HR, Guan L. Structure-based mechanism for Na(+)/melibiose symport by MelB. Nat Commun. 2014;5:3009.
• Ciribilli Y, Monti P, Bisio A, Nguyen T, Ethayathulla AS, Ramos A, Foggetti G, Menichini P, Menendez D, Resnick M, Viadiu H, Fronza G, Inga A. Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code. Nucleic Acids Res. 2013 Oct;41(18):8637-53.
• Ethayathulla AS, Nguyen HT, Viadiu H. Crystal Structures of the DNA-binding Domain Tetramer of the p53 Tumor Suppressor Family Member p73 Bound to Different Full-site Response Elements. J Biol Chem. 2013; 288(7):4744-54.
• Ethayathulla AS, Tse P, Monti P, Nguyen S, Inga A, Fronza G, Viadiu H. Structure of p73 DNA-Binding Domain Tetramer Modulates p73 Transactivation. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6066-71.
• Soni BR, Hasan MI, Parmar A, Ethayathulla AS, Kumar RP, Singh NK, Sinha M, Kaur P, Yadav S, Sharma S, Madamwar D, Singh TP. Structure of the novel 14kDa fragment of alpha-subunit of phycoerythrin from the starving cyanobacterium Phormidium tenue. J Struct Biol. 2010 171(3):247-55.
• Mishra P, Prem Kumar R, Ethayathulla AS, Singh N, Sharma S, Perbandt M, Betzel C, Kaur P, Srinivasan A, Bhakuni V, Singh TP. Polysaccharide binding sites in hyaluronate lyase--crystal structures of native phage-encoded hyaluronate lyase and its complexes with ascorbic acid and lactose. FEBS J. 2009 276(12):3392-402.
• Ethayathulla AS, Bessho Y, Shinkai A, Padmanabhan B, Singh TP, Kaur P, Yokoyama S. Purification, crystallization and preliminary X-ray diffraction analysis of the putative ABC transporter ATP-binding protein from Thermotoga maritima. Acta Crystallogr Sect F. 2008 (64) 498-500.

Selected Publications/Patents (Last 5 years):

• Koley T, Goswami A, Kumar M, Upadhyay N, Hariprasad G*. Comparative structural analysis of human ACE2 receptor with spike protein of SARS-CoV-2 variants: Implications to understand infectivity of the virus. Advances and Applications in Bioinformatics and Chemistry (2022) 15: 21-27.
• Kaushik A , Bandyopadhyay S, Porwal C, Srinivasan A, Rukmangadachar LA, Hariprasad G, Kola S, Kataria J, Singh UB. 2D-DIGE based urinary proteomics and functional enrichment studies to reveal novel Mycobacterium tuberculosis and human protein biomarker candidates for pulmonary tuberculosis Biochemistry Biophysics Research Communications (2022) 619:15-21.
• Pathania S, Khan MI, Bandyopadhyay S, Singh SS, Rani K, Parashar TR, Jayaram J, Mishra PR, Srivastava A, Mathur S, Hari S, Vanamail P, Hariprasad G*. iTRAQ proteomics of sentinel lymph nodes for identification of extracellular matrix proteins to flag metastasis in early breast cancer. Scientific Reports (2022) 12(1):8625.
• Koley T, Kumar M, Goswami A, Ethayathulla AS, Hariprasad G*. Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virus. Biochemical and Biophysics Research Communications. (2022) 592:51-53.
• Naqvi AAT, Fatima K, Mohammad T, Fatima U, Singh IK, Singh A, Atif SM, Hariprasad G, Hasan GM, Hassan MI. Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach. BBA Molecular Basis of Disease (2020) 1866: 165878.
• Khan MI, Hariprasad G*. Structural Modeling of Wild and Mutant Forms of Human Plasma Platelet Activating Factor-Acetyl Hydrolase Enzyme. Journal of Inflammation Research. (2020) 13:1125-1139.
• Khan MI, Hariprasad G*. Human Secretary Phospholipase A2 Mutations and Their Clinical Implications. Journal of Inflammation Research. (2020) 13: 551-561.
• Patania S, Khan MI, Kumar A, Gupta AK, Rani K, Parashar TR, Jayaram J, Mishra PR, Srivastava A, Mathur S, Hari S, Hariprasad G*. Proteomics of sentinel lymph nodes in early breast cancer for identification of thymidylate synthase as a potential biomarker to flag metastasis: A preliminary study. Cancer Management and Research (2020) 12: 4841–4854.
• Gupta AK, Pokhriyal R, Das U, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachanran R, Goyal V, Tripathi M, Hariprasad. G*. Evaluation of α-synuclein and apolipoprotein E as potential biomarkers in CSF to monitor pharmaco-therapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15:2073-2085.
• Gupta AK, Pokhriyal R, Khan MI, Kumar DR, Gupta R, Chadda RK, Ramachanran R, Goyal V, Tripathi M, Hariprasad. G*. Cerebrospinal fluid proteomics for identification of α2-macroglobulin as a potential biomarker to monitor pharmacological therapeutic efficacy in dopamine dictated disease states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15:2853-2867.
• Gupta AK, Kumar GK, Rani K, Pokhriyal R, Khan MI, Kumar DR, Goyal V, Tripathi M, Gupta R, Chadda RK, Vanamail P, Mohanty AK, Hariprasad. G*. 2D-DIGE as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine dictated states of Parkinson’s disease and schizophrenia. Neuropsychiatric Disease Treatment. (2019) 15: 1031-1044.
• Gupta AK, Rani K, Swarnkar S, Kumar GK, Khan MI, Pokhriyal R, Kumar DR, Goyal V, Tripathi M, Gupta R, Chadda RK, Vanamail P, Hariprasad G*. Evaluation of Serum Apolipoprotein E as a Potential Biomarker for Pharmacological Therapeutic Efficacy Monitoring in Dopamine Dictated Disease Spectrum of Schizophrenia and Parkinson's disease: A Preliminary Study. J Cent Nerv Syst Dis. (2018) 10:1179573518803585. eCollection.