Selected Publications/Patents (Last 5 years):

• Abhinay Kumar Singh, Atul Batra, Ashish Datt Upadhaya, Subhash Gupta, Haresh K P and Sharmistha Dey, Circulatory Level of Inflammatory Cytoskeleton Signaling Regime Proteins in Cancer Invasion and Metastasis. Front. Oncol. 2022; 12:851807. doi: 10.3389/fonc.2022.851807
• Masroor Anwar, Rashmita Pradhan, Sharmistha Dey, Rahul Kumar. The Role of Sirtuins in Sarcopenia and Frailty Ageing and Disease. 2022; Volume 14, Number 1; doi.org/10.14336/AD.2022.0622
• Sharmistha Dey, Abhay Kumar Singh, Abhinay Kumar Singh, Kartik Rawat, Joyita Banerjee, Vertica Agnihotri, Deepak Upadhaya. Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention. Medical Oncology 2022; 39:30. doi.org/10.1007/s12032-021-01633-4
• Pradhan R, Singh AK, Kumar P, Bajpai S, Pathak M, Chatterjee P, Dwivedi S, Dey AB, Dey S. Blood Circulatory Level of Seven Sirtuins in Alzheimer's Disease: Potent Biomarker Based on Translational Research. Mol Neurobiol. 2022 Jan 7. 59, pages1440–1451. doi: 10.1007/s12035-021-02671-9. Citation: 2
• Kumari S, Singh A, Singh AK, Yadav Y, Bajpai S, Kumar P, Upadhyay AD, Shekhar S, Dwivedi S, Dey AB, Dey S. Circulatory GSK-3β: Blood-Based Biomarker and Therapeutic Target for Alzheimer's Disease. J Alzheimers Dis. 2022;85(1):249-260. doi: 10.3233/JAD-215347
• Masroor Anwar, Saumya Ranjan Mallick, Daizy Paliwal, Shashank Shekhar, Subrat Kumar Panda, Sharmistha Dey, Aparajit Ballav Dey. Impact of physical activity on mitochondrial enzymes, muscle stem cell and anti-oxidant protein Sestrins in Sarcopenic mice. Experimental Gerontology. 2021, Volume 150, 111358. DOI: 10.1016/j.exger.2021.111358. Citation: 3
• Kumar R, Tiwari V, Dey S. Role of proline-rich tyrosine kinase 2 (Pyk2) in the pathogenesis of Alzheimer's Disease. Eur J Neurosci. 2021 doi: 10.1111/ejn.15569. Online ahead of print.
• Banerjee J, Gupta A, Agnihotri V, Pradhan R, Kandel R, Upadhyay AD, Dwivedi S, Kumar L, Dey S, Dey AB. Lung cancer in the older population:Interactive effects of angiotensin converting enzyme gene polymorphism (rs 4340 ID) and tobacco addiction in risk assessment. Indian J Cancer. 2021 Jun 21. doi: 10.4103/ijc.IJC_1082_19. Online ahead of print.
• Pradhan R, Yadav SK, Prem NN, Bhagel V, Pathak M, Shekhar S, Gaikwad S, Dwivedi SN, Bal CS, Dey AB, Dey S. Serum FOXO3A: A ray of hope for early diagnosis of Alzheimer's disease. Mech Ageing Dev. 2020;190:111290. doi: 10.1016/j.mad.2020.111290. Citation: 6
• Rajan SP, Anwar M, Jain B, Khan MA, Dey S, Dey AB. Serum sestrins: potential predictive molecule in human sarcopenia. Aging Clin Exp Res. 2020, 33, 1315-1324. doi: 10.1007/s40520-020-01642-9. Citation: 4
• Singh AP, Nigam L, Yadav Y, Shekhar S, Subbarao N, Dey S. Design and in vitro analysis of SIRT2 inhibitor targeting Parkinson's disease. Mol Divers. 2020; 25, 2261-2270. doi: 10.1007/s11030-020-10116-z. Citation: 2
• Vertica Agnihotri, Abhishek Gupta, Lalit Kumar, Sharmistha Dey. Serum sHLA-G: Significant diagnostic biomarker with respect to therapy and immunosuppressive mediators in Head and Neck Squamous Cell Carcinoma. Sci Rep. 2020; 10: 3806. Published online 2020 Mar 2. doi: 10.1038/s41598-020-60811-y. Citation: 6
• Rai N, Dey S. Protective response of Sestrin under stressful conditions in aging. Ageing Res Rev. 2020; 64:101186. doi: 10.1016/j.arr.2020.101186. Citation: 5
• Nitish Rai, Ashish Datt Upadhyay, Vinay Goyal, Sadanand Dwivedi, Aparajit Ballav Dey, Sharmistha Dey Sestrin2 as Serum Protein Marker and Potential Therapeutic Target for Parkinson's Disease. J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):690-695. doi: 10.1093/gerona/glz234. Citation: 13
• Shekhar S, Dey S Induction of p73, Δ133p53, Δ160p53, pAKT lead to neuroprotection via DNA repair by 5-LOX inhibition. Mol Biol Rep. 2020; 47(1), 269-274. doi: 10.1007/s11033-019-05127-5. Citation: 4
• Singh AP, Ramana G, Bajaj T, Singh V, Dwivedi S, Behari M, Dey AB, Dey S. Elevated Serum SIRT 2 May Differentiate Parkinson's Disease From Atypical Parkinsonian Syndromes. Front Mol Neurosci. 2019;12:129. doi: 10.3389/fnmol.2019.00129. eCollection 2019. Citation: 7
• Sahu V, Mohan A, Dey S. p38 MAP kinases: plausible diagnostic and prognostic serum protein marker of non small cell lung cancer. Exp Mol Pathol. 2019;107:118-123. Citation: 6
• Shekhar S, Yadav Y, Singh AP, Pradhan R, Desai GR, Dey AB, Dey S. Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer's disease like pathology via maintaining oxidative balance through SIRT1 pathway. Exp Gerontol. 2018;110:277-283. Citation: 16
• Sahu V, Nigam L, Agnihotri V, Gupta A, Shekhar S, Subbarao N, Bhaskar S, Dey S. Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same. Cancer Res Treat. 2019; 51(1):313-325. doi: 10.4143/crt.2018.105. Citation: 15
• Singh AP, Bajaj T, Gupta D, Singh SB, Chakrawarty A, Goyal V, Dey AB, Dey S. Serum Mortalin Correlated with α-Synuclein as Serum Markers in Parkinson's Disease: A Pilot Study. Neuromolecular Med. 2018;20(1):83-89. doi: 10.1007/s12017-017-8475-5. Citation: 17
• Rai N, Venugopalan G, Pradhan R, Ambastha A, Upadhyay AD, Dwivedi S, Dey AB, Dey S. Exploration of Novel Anti-Oxidant Protein Sestrin in Frailty Syndrome in Elderly. Aging Dis. 2018; 9(2):220-227. doi: 10.14336/AD.2017.0423. Citation: 21
• Shekhar S, Yadav SK, Rai N, Kumar R, Yadav Y, Tripathi M, Dey AB, Dey S. 5-LOX in Alzheimer's Disease: Potential Serum Marker and In Vitro Evidences for Rescue of Neurotoxicity by Its Inhibitor YWCS. Mol Neurobiol. 2018;55(4):2754-2762. doi: 10.1007/s12035-017-0527-1. Citation: 12
• Kumar R, Nigam L, Singh AP, Singh K, Subbarao N, Dey S. Design, synthesis of allosteric peptide activator for human SIRT1 and its biological evaluation in cellular model of Alzheimer's disease. Eur J Med Chem. 2017;127:909-916. doi: 10.1016/j.ejmech.2016.11.001. Citation: 31
• Kumar S, Sharma VK, Yadav S, Dey S. Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway. Chem Cent J. 2017;11(1):56. doi: 10.1186/s13065-017-0281-5. Citation: 13
• Vertica Agnihotri, Abhishek Gupta, Rahul Kumar, Ashish Datt Upadhyay, Sadanand Dwivedi, Lalit Kumar, Sharmistha Dey. Promising link of HLA-G polymorphism, tobacco consumption and risk of Head and Neck Squamous Cell Carcinoma (HNSCC) in North Indian population. Human Immunology 78 (2017) 172–178. Citation: 18
• Gupta A, Agnihotri V, Kumar R, Upadhyay AD, Bhaskar S, Dwivedi S, Dey S. Effects of Tobacco Habits on the Polymorphism of NFKB1 and NFKB1A Gene of Head and Neck Squamous Cell Carcinoma in Indian Population. Asian Pac J Cancer Prev. 2017;18(7):1855-1859. Citation: 18
• Pradhan R, Kumar R, Shekhar S, Rai N, Ambashtha A, Banerjee J, Pathak M, Dwivedi SN, Dey S, Dey AB. Longevity and healthy ageing genes FOXO3A and SIRT3: Serum protein marker and new road map to burst oxidative stress by Withania somnifera. Exp Gerontol. 2017;95:9-15. May 2012. Volume 3, Issue 2, 2012, pp.-49-54. Citation: 10

Selected Publications/Patents (Last 5 years):

• Ahmad N, Singh A, Gupta A, Pant P, Singh TP, Sharma S, Sharma P. Discovery of the Lead Molecules Targeting the First Step of the Histidine Biosynthesis Pathway of Acinetobacter baumannii. J Chem Inf Model. (2022) 62:1744-1759.
• Smith ML, Sharma S, Singh TP. Comments on the Discussion Forum: Oromucosal immunomodulation as clinical spectrum mitigating factor in SARS-CoV-2 infection. Scand J Immunol. (2022) 95:e13111.
• Sikarwar J, Singh J, Singh TP, Sharma P, Sharma S. The mechanism of action of Lactoferrin - Nucleoside Diphosphate Kinase complex in combating biofilm formation. Protein Pept Lett. (2022) Aug 16. doi: 10.2174/0929866529666220816160517.
• Singh PK, Ahmad N, Yamini S, Singh RP, Singh AK, Sharma P, Smith ML, Sharma S, Singh TP. Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase. Protein Sci. (2022) 31:384-395.
• Singh J, Maurya A, Singh PK, Viswanathan V, Ahmad MI, Sharma P, Sharma S, Singh TP. A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 Å Resolution. Protein J. (2021) 40:857-866.
• Smith, M. L., Sharma, S., & Singh, T. P. Iodide supplementation of the anti-viral duox-lactoperoxidase activity may prevent some SARS-CoV-2 infections. Eur. J. Clin. Nutr. (2022). 1–2. 76(4):629-630.
• Gupta A, Vijayan V, Pant P, Kaur P, Singh TP, Sharma P, Sharma S. Structure prediction and discovery of inhibitors against phosphopantothenoyl cysteine synthetase of Acinetobacter baumannii. J Biomol Struct Dyn. (2021) Aug 4:1-13
• Singh A, Ahmad N, Varadarajan A, Vikram N, Singh TP, Sharma S, Sharma P. Lactoferrin, a potential iron-chelator as an adjunct treatment for mucormycosis - A comprehensive review. Int J Biol Macromol. (2021) Sep 30;187:988-998.
• Singh J, Vijayan V, Ahmedi S, Pant P, Manzoor N, Singh TP, Sharma P, Sharma S. Lactosmart: A Novel Therapeutic Molecule for Antimicrobial Defense. Front Microbiol. (2021) 12:672589.
• Gupta A, Sharma P, Singh TP & Sharma S. Phosphopantetheine Adenylyltransferase: A promising drug target to combat antibiotic resistance. Biochim Biophys Acta Proteins Proteom (2021) 1869:140566.
• Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S & Singh TP Structure of Yak Lactoperoxidase at 1.55 Å Resolution. Protein J. (2021) 40:8-18.
• Singh PK, Pandey S, Rani C, Ahmad N, Viswanathan V, Sharma P, Kaur P, Sharma S & Singh TP. Potassium-induced partial inhibition of lactoperoxidase: structure of the complex of lactoperoxidase with potassium ion at 2.20 Å resolution. J Biol Inorg Chem (2021) 26: 149-159
• Sharma P, Singla A, Gupta A, Khan NI, Rani C, Singh TP & Sharma S. Biophysical characterization of Type III Pantothenate kinase (PanK) from Acinetobacter baumannii. Protein Pept Lett (2021) 28(4), 450-458.
• Sharma P, Vijayan V, Pant P, Sharma M, Vikram N, Kaur P, Singh TP, Sharma S. Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2. J Biomol Struct Dyn. 2020; 3:1-11
• Gupta A, Singh PK, Iqbal N, Sharma P, Baraigya HR, Kaur P, Umar MS, Ahmad F, Sharma A, Owais M, Sharma S, Singh TP. Structural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Biochim Biophys Acta Proteins Proteom. (2019) 1867:537-547.
• Pandey SN, Iqbal N, Singh PK, Rastogi N, Kaur P, Sharma S & Singh TP. Binding and structural studies of the complexes of type 1 ribosome inactivating protein from Momordica balsamina with uracil and uridine. Proteins. (2019) 87:99-109.
• Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S & Singh TP. A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. (2018) 644:72-80
• Kaushik S, Iqbal N, Singh N, Sikarwar JS, Singh PK, Kaur P, Sharma S & Singh TP. Search of multiple hot spots on the surface of peptidyl-tRNA hydrolase: structural, binding and antibacterial studies. Biochem J. (2018) 475:547-560.
• Singh PK, Iqbal N, Sirohi HV, Bairagya HR, Kaur P, Sharma S & Singh TP. Structural basis of activation of mammalian heme peroxidases. Prog Biophys Mol Biol. (2018)133:49-55.
• Singh PK, Sirohi HV, Iqbal N, Tiwari P, Kaur P, Sharma S, Singh TP. Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98Å resolution. Biochim Biophys Acta. (2017) 1865:329-335.
• Iqbal N, Kumar M, Sharma P, Yadav SP, Kaur P, Sharma S, Singh TP. Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii. Int J Biol Macromol. (2017) 94:459-465.
• Khan SH, Islam A, Hassan MI, Sharma S, Singh TP, Ahmad F.Effect of conservative mutations (L94V and L94I) on the structure and stability of horse cytochrome c. Arch Biochem Biophys. (2017) 633:40-49
• Sirohi HV, Singh PK, Iqbal N, Sharma P, Singh AK, Kaur P, Sharma S, Singh TP. Design of anti-thyroid drugs: Binding studies and structure determination of the complex of lactoperoxidase with 2-mercaptoimidazole at 2.30 Å resolution. Proteins. (2017) 85:1882-1890.
• Singh RP, Singh A, Sirohi HV, Singh AK, Kaur P, Sharma S, Singh TP. Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases - structural determination of the lactoperoxidase-methimazole complex at 1.97 Å resolution. FEBS Open Bio. (2016) 6:640-50.
• Rastogi N, Singh A, Singh PK, Tyagi TK, Pandey S, Shin K, Kaur P, Sharma S, Singh TP. Structure of iron saturated C-lobe of bovine lactoferrin at pH 6.8 indicates a weakening of iron coordination. Proteins. (2016) 84:591-9.

List of Books:

• Warriors in White (11 January 2021). ISBN 978-1-637455-11-1.
• A Dragonfly's Purpose. (12 September 2019). ISBN 978-1-64650-765-8.
• The Secret of the Red Crystals. (16 October 2017). ISBN 978-1-947988-83-5
• Kovi’s Promise (21 November 2021) ISBN 979-8-885037-77-8
• Tumhara Bholu (23 November 2021) ISBN 979-8-885039-02-4

Selected Publications/Patents (Last 5 years):

• Chhikara N, Tomar AK, Datta SK, Yadav S. Proteomic changes in human spermatozoa during in vitro capacitation and acrosome reaction in normozoospermia and asthenozoospermia. Andrology. 2022 Sep 4. doi:10.1111/andr.13289. Epub ahead of print. PMID: 36057948.
• Naglot S, Tomar AK, Singh N, Yadav S. Label-free proteomics of spermatozoa identifies candidate protein markers of idiopathic recurrent pregnancy loss. Reprod Biol. 2021;21(3):100539.
• Saini A, Chandra KB, Kumar V, Mathur SR, Sharma JB, Kumar S, Yadav S. Analysis of Multimerin 1 (MMRN1) expression in ovarian cancer. Mol Biol Rep. 2020;47(12):9459-9468.
• Jain P, Ojha SK, Kumar V, Bakhshi S, Singh S, Yadav S. Differential seminal plasma proteome signatures of acute lymphoblastic leukemia survivors. Reprod Biol. 2019;19(4):322-328.
• Sinha A, Singh V, Singh S, Yadav S. Proteomic analyses reveal lower expression of TEX40 and ATP6V0A2 proteins related to calcium ion entry and acrosomal acidification in asthenozoospermic males. Life Sci. 2019;218:81-88.

Publications:

• Gupta D, Tiwari P, Haque MA, Sachdeva E, Hassan MI, Ethayathulla AS, Kaur P. (2021) Structural insights into the transient closed conformation and pH dependent ATPase activity of S.Typhi Gyrase B N- terminal domain. Arch Biochem Biophys. Apr 15; 701:108786. doi: 10.1016/j.abb.2021.108786.
• Gupta D, Sharma P, Singh M, Kumar M, Ethayathulla AS, Kaur P. (2021) Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants. Cell Mol Life Sci. 78:7967-7989. doi: 10.1007/s00018-021-04008-0. (Review)
• Tripathi MK, Nath A, Singh TP, Ethayathulla AS, Kaur P (2021) Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery Mol Divers 25(3):1439-1460. doi: 10.1007/s11030-021-10256-w.
• Katiyar A, Kaur G, Rani L, Jena L, Singh H, Kumar L, Sharma A, Kaur P*, Gupta R*. (2021) Genome-wide identification of potential biomarkers in multiple myeloma using meta-analysis of mRNA and miRNA expression data. Sci Rep. 11(1):10957. doi: 10.1038/s41598-021-90424-y. (Co-Corresponding authors)
• Singh PK, Pandey S, Rani C, Ahmad N, Viswanathan V, Sharma P, Kaur P, Sharma S, Singh TP (2021) Potassium-induced partial inhibition of lactoperoxidase: structure of the complex of lactoperoxidase with potassium ion at 2.20 Å resolution. J Biol Inorg Chem. 26(1):149-159. doi: 10.1007/s00775-020-01844-6.
• Singh PK, Sharma P, Bhushan A, Kaur P, Sharma S, Singh TP. (2021) Structure of a ternary complex of lactoperoxidase with iodide and hydrogen peroxide at 1.77 Å resolution. J Inorg Biochem. 220:111461. doi: 10.1016/j.jinorgbio.2021.111461.
• Sharma P, Vijayan V, Pant P., Vikram N, Kaur P, Singh, TP, Sharma S (2021) Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2. J. Biomol Struct Dyn 39(17):6649-6659.
• Vijayan V, Pant P., Vikram N, Kaur P, Singh, TP, Sharma S, Sharma P (2021) Identification of promising drug candidates against NSP16 of SARS-CoV-2 through computational drug repurposing study. J. Biomol Struct Dyn 39(17):6713-6727.
• Gupta A, Vijayan V, Pant P., Kaur P, Singh, TP, Sharma P, Sharma S (2021) Structure prediction and discovery of inhibitors against phosphopanthothenoyl cysteine synthetase of Acinetobacter baumannii. J. Biomol Struct Dyn Aug 4:1-13.
• Singh M, Malhotra L, Haque MA, Kumar M, Tikhomirov A, Litvinova V, Korolev AM, Ethayathulla AS, Das U, Shchekotikhin AE, Kaur P. (2021) Heteroarene-fused anthraquinone derivatives as potential modulators for human aurora kinase B. Biochimie. 182:152-165. doi: 10.1016/j.biochi.2020.12.024.
• Viswanathan V, Rani C, Ahmad N, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP. (2021) Structure of Yak Lactoperoxidase at 1.55 Å Resolution. Protein J. 40: 8-18. doi: 10.1007/s10930-020-09957-2. .PMID: 33389415
• Koley T, Madaan S, Chowdhury SR, Kumar M, Kaur P, Singh TP, Ethayathulla AS. (2021) Structural analysis of COVID-19 spike protein in recognizing the ACE2 receptor of different mammalian species and its susceptibility to viral infection. 3 Biotech.11(2):109. doi: 10.1007/s13205-020-02599-2. Epub 2021 Feb 1.PMID: 33552834
• Malhotra L, Goyal HKV, Jhuria S, Dev K, Kumar S, Kumar M, Kaur P, Ethayathulla AS. (2021) Curcumin rescue p53Y220C in BxPC-3 pancreatic adenocarcinomas cell line: Evidence-based on computational, biophysical, and in vivo studies. Biochim Biophys Acta Gen Subj. 1865:129807. doi: 10.1016/j.bbagen.2020.129807.
• Gupta A, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP. (2020) Structural and biochemical studies of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with dephospho-coenzyme A and coenzyme A. Int J Biol Macromol. 142:181-190. doi: 10.1016/j.ijbiomac.2019.09.090.
• Gupta A, Rani C, Pant P, Vijayan V, Vikram N, Kaur P, Singh TP, Sharma S, Sharma P. (2020) Structure-Based Virtual Screening and Biochemical Validation to Discover a Potential Inhibitor of the SARS-CoV-2 Main Protease.ACS Omega. 5:33151-33161. doi: 10.1021/acsomega.0c04808.
• Naz F, Mashkoor M, Sharma P, Haque MA, Kapil A, Kumar M, Kaur P, Abdul Samath E. (2020) Drug repurposing approach to target FtsZ cell division protein from Salmonella Typhi. Int J Biol Macromol. 159:1073-1083. doi: 10.1016/j.ijbiomac.2020.05.063.
• Sachdeva, E., Kaur, G., Tiwari, P., Gupta, D, Singh TP, Ethayathulla, AS, Kaur P. (2020). The pivot point arginines identified in the β-pinwheel structure of C-terminal domain from Salmonella Typhi DNA Gyrase A subunit. Sci Rep 10, 7817 https://doi.org/10.1038/s41598-020-64792-w
• Tripathi MK, Singh P, Sharma S, Singh TP, Ethayathulla AS, Kaur P (2020) Identification of bioactive molecule from Withania somnifera (Ashwagandha) as SARS-CoV-2 main protease inhibitor J. Biomol Struc. Dyn. doi.org/10.1080/07391102.2020.1790425
• Katiyar A, Sharma P, Dahiya S, Singh H, Kapil A, Kaur P (2020) Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India. Sci. Rep. 10:8299. doi: 10.1038/s41598-020-64934-0.
• Sharma P, Vijayan V , Pant P, Sharma M, Vikram N, Kaur P, Singh TP, Sharma S (2020) Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2 J. Biomol Struc. Dyn. doi.org/10.1080/07391102.2020.1798286
• Bansal R Haque MA, Hassan MI, Ethayathulla AS, Kaur P. (2020) Structural and conformational behavior of MurE ligase from Salmonella enterica serovar Typhi at different temperature and pH conditions Int J Biol Macromol. 150:389-399. doi: 10.1016/j.ijbiomac.2020.01.306
• Tiwari A, Kumar M, Kaur P, Kumar B, Sagi SSK (2020) Efficacy of Quercetin as a potent sensitizer of β2 AR in combating the impairment of fluid clearance in lungs of rats under hypoxia. Respiratory Physiology & Neurobiology 273: 103334
• Verma D, Gupta S, Saxena R, Kaur P, Srivastava S, Gupta V. (2020) Allosteric inhibition and kinetic characterization of Klebsiella pneumoniae CysE: An emerging drug target. Int J Biol Macromol. 151:1240‐1249. doi:10.1016/j.ijbiomac.2019.10.170
• Kumar A, Jain V, Chowdhury MR, Kumar M, Kaur P, Kabra M. (2020) Pathogenic/likely pathogenic variants in the SHOX, GHR and IGFALS genes among Indian children with idiopathic short stature. J Pediatr Endocrinol Metab 33:79-88. doi: 10.1515/jpem-2019-0234.

Recent Chapter in Book:

• Tripathi, MK, Sharma, S, Singh, TP, Ethayathulla, AS, Kaur P (2021) Computational Intelligence in Drug Repurposing for COVID-19 in 'Computational Intelligence Methods in COVID-19: Surveillance, Prevention, Prediction and Diagnosis" in the series Studies in Computational Intelligence', Pg 273 - 294 Ed. Khalid Raza Springer Singapore

Selected Publications/Patents(Last 5 years)

• Gupta A, Singh PK, Sharma P, Kaur P, Sharma S, Singh TP. (2019). Structural and biochemical studies of phosphopantetheine adenylyltransferase from Acinetobacter baumannii with dephospho-coenzyme A and coenzyme A. Int J Biol Macromol. S0141-8130(19) : 35145-1.
• Chaudhary A, Kumar V, Singh PK, Sharma P, Bairagya HR, Kaur P, Sharma S, Chauhan SS, Singh TP. (2018) A glycoprotein from mammary gland secreted during involution promotes apoptosis: Structural and biological studies. Arch Biochem Biophys. 644:72-80.
• Sharma, S., Kaushik, S., Sinha, M., Singh, A., Sikarwar, J., Chaudhary, A., Gupta, A., Kaur, P. & Singh, T.P. (2014). Structural and functional insights into Peptidyl-tRNA Hydrolase. Biochem. Biophys. Acta.1844: 1279-1288
• Structure and binding studies of proliferating cell nuclear antigen from Leishmania donovani. (2017) Yadav SP, Singh PK, Sharma P, Iqbal N, Kaur P, Sharma S, Singh TP. Biochim Biophys Acta Proteins Proteom. 1865:1395-1405.
• Singh PK, Sirohi HV, Iqbal N, Tiwari P, Kaur P, Sharma S, Singh TP. (2017) Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98Å resolution. Biochim Biophys Acta Proteins Proteom. 1865:329-335.
• Rastogi, N., Singh. A., Pandey, S.N., Sinha, M., Bhushan, A., Kaur, P. & Singh, T.P. (2014). Structure if the iron-free true C-terminal half of bovine lactoferrin produced by tryptic digestion and its functional significance in the gut. FEBS J. 281: 2871-2872.
• Kaushik, S., Singh, N., Yamini, S., Singh, A., Sinha, M., Arora, A., Kaur, P., Sharma, S. & Singh, T.P. (2013). The Mode of Inhibitor Binding to Peptidyl-tRNA Hydrolase: Binding Studies and Structure Determination of Unbound and Bound Peptidyl-tRNA Hydrolase from Acinetobacter baumannii. PLoS One. 8, e67547.
• Kushwaha, G.S., Pandey, N., Sinha, M, Kaur, P., Sharma, S. & Singh, T.P. (2012) Crystal structures of a type-1 ribosome inactivating protein from Momordica balsamina in the bound and unbound states.Biochim Biophys Acta. 1824 :679-691.
• Sharma, P., Dube, D., Sinha, M., Mishra, B., Dey, S., Mal, G., Pathak, K.M.L., Kar, P., Sharma, S. & Singh, T.P. (2011). Multi-ligand specificity of pathogen associated molecular-binding site in peptidoglycan recognition protein. J. Biol. Chem. 286 : 31723-31730
• Sharma, P., Dube, D., Singh, A., Mishra, B., Singh, N., Sinha, M., Dey, S., Kaur, P., Mitra, D.K., Sharma, S. & Singh, T.P. (2011). Structural basis of recognition of pathogen-associated molecular patterns and inhibition of pro-inflammatory cytokines by camel peptidoglycan recognition protein. J. Biol Chem. 286 : 16208-16217.
• Singh, A.K., Kumar, R.P., Pandey, N., Singh, N., Sinha, M., Bhushan, A.,Kaur, P., Sharma, S. & Singh, T.P. (2009). Mode of binding of the tuberculosis prodrug isoniazid to peroxidases: Crystal structure of bovine lactoperoxidase with isoniazid at 2.7A resolution. J. Biol. Chem. 285, 1569-1576
• Mir, R., Singh, N., Vikram, G., Kumar, R.P., Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Structural basis of the prevention NSAID-induced damage of the gastrointestinal tract by C-terminal half (C-lobe)of bovine colostrums protein lactoferrin: Binding andstructural studies of the C-lobe complexes with indomethacin, diclofenac, aspirin and ibuprofen. Biophys. J. 97, 3178-3186
• Singh, A.K., Singh, N., Sinha, M., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications : Crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid and benzylhydroxamic acid.J. Biol. Chem. 284, 20311-20318.
• Sheikh, I.A., Singh, A.K., Singh, N., Sinha, M., Singh, S.B., Bhushan, A., Kaur, P., Srinivasan, A., Sharma, S. & Singh, T.P. (2009). Structural evidence of substrate specificity in mammalian peroxidases: Structure of the thiocyanate complex with lactoperoxidase and its interactions at 2.4A resolution. J. Biol. Chem. 284, 14849-14856.
• Singh, A.K., Singh, N., Sharma, S., Shin, K., Takase, M., Kaur, P., Srinivasan, A. & Singh, T.P. (2009). Inhibition of lactoperoxidase by its own catalytic product: Crystal structure of the hypothiocyanate-inhibited bovine lactoperoxidase at 2.3A resolution. Biophys. J. 96, 646-654.